Cerebral Infrared Spectroscopy in Neuromonitoring of Newborns with Hypoxicischemic Encephalopathy
DOI:
https://doi.org/10.61788/njn.v1i22.01Keywords:
hypoxicischemic encephalopathy, newborn, infrared spectroscopyAbstract
The review presents literature data on the basic principles of using infrared spectroscopy (ICS) for clinical studies of cerebral oxygenation in newborns with hypoxicischemic encephalopathy. The results of using ICS for monitoring cerebral oxygenation and mitochondrial oxidative metabolism are presented.
References
Verhagen EA., Van Braeckel KN. Van der Veere CN et al. Cerebral oxygenation is associated with neurodevelopmental outcome of preterm children of age 2 to 3 years // Dev Med Child Neurol 2015, 57:449-55.
Borch K, Lou HC, Gzeisen G. Cerebral white matter blood flow and arterial blood pressure in preterm infants // Acta Pediatr 2016; 99; 1489-92.
Wong FY., Silas R., Hew S. et al. Cerebral oxygenation is highly sensitive to blood pressure variability in sick preterm infants // Plos One 2012;7;e43165.
Meek JH., Elwell CE., McCormick DS. et al. Abnormal cerebral hemodynamics in prenatally asphyxiated neonates related to outcome // Arch Dis Fetal Neonatal Ed. 1999, 81:F110-FS.10.1136/fn.81.2.[Pub Med].
Hassel KJ, Ezzati M., Alonso-Alconada D. et al. New horizons for newborn brain protection: enhancing endogenous neuroproteetion // Arch Dis Child Fetal Neonatal Ed. (2015). 100:F 541-52.10.1136.[Pub Med].
Mitra S, Kendall GS, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, et al. Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia // Arch Dis Child Fetal Neonatal Ed. 2019, 104:F424-32. 10.1136/archdischild-2018- 315478 [PubMed-[CrossRef] [Google Scholar].
Lally PJ, Montaldo P, Oliveira V, Soe A, Swamy R, Bassett P, et al. Marble consortium. Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study // Lancet Neurol. 2019, 18:35-45. 10.1016/S1474-4422(18)30325-9 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Manja V, Saugstad OD., Lakshminrusimha S. Oxygen saturation targets in preterm infants and outcomes at 18-24 month: a systematic review // Pediatrics, 2017; 139(1):e20161609.
Marin T., Moore J. Understanding near-infared spectroscopy // Adv Neonatal Care. 2014;11:382-8.
Bickler PE., Feiner JR., Rollins MD. Factors affecting the performance of 5 brain oxymeters during hypoxia in healthy volunteers // Anesth.Analg 2013.vol.117-p.813-23.
Weiss M., Vutskits L., Hansan T.G., Engelharti T. Safe anesthesia for each purpose: the SAFETOTS initiative // Curr.Opin.Anaesthesiol. 2015.-v.-28.p.302-7.
Dix LM, van Bel F, Lemmers PM. Monitoring cerebral oxygenation in neonates: an update // Front Pediatr. 2017, 5:46 10.3389/fped.2017.00046 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Garvey AA, Dempsey EM. Applications of near infrared spectroscopy in the neonate // Curr Opin Pediatr. 2018, 30:209-15. 10.1097/ MOP.0000000000000599 [PubMed] [CrossRef] [Google Scholar].
Almaazmi M, Schmid MB, Havers S, Reister F, Lindner W, Mayer B. et al. Cerebral near- infrared spectroscopy during transition of healthy term newborns // Neonatology. 2013, 103:246-51. 10.1159/000345926 [PubMed] [CrossRef] [Google Scholar].
Toet MC, Lemmers PMA, van Schelven LJ, van Bel F. Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome // Pediatrics. 2006, 117:333-9. 10.1542/peds.2005-0987 [PubMed] [CrossRef] [Google Scholar].
Van Bel F, Dorrepaal CA, Benders MJNL, Zeeuwe P.EM. Van de Bor M, Berger HM. Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia // Pediatrics. 1993, 92:365-72. [PubMed] [Google Scholar].
Bale G., Elwell C.E, Tachlsidis I. From Jöbsis to the present day: a review of clinical near- infrared spectroscopy measurements of cerebral cytochrome-c-oxidase // J Biomed Opt. (2016) 21:099801 10.1117/1.JBO.21.9.099801 [PubMed] [CrossRef] [Google Scholar].
Pichler G et al. How to monitor the brain during immediate neonatal transition and resuscitation? A systematic qualitative review of the literature // Neonatology. 2014.vol.2015, №3.p.205-210.
Kratky E. et al. Regional cerebral oxygen saturation in newborn infants in the first 15 min of life after vaginal deliveery // Physiol.Meas.2018.v.3.-№1.p.95-102.
Hyttel-Sorensen S. et al. A phose II randomized clinical trial on cerebral near-infrared spectroscopy plus a treatment guideline versus treatment as usual for extremely preterm infants during the first three days of life (Safe BoosC): study protock for a randomized controlled trial // Trials.2013.vol.14.p.120.
NcNeills et al. Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infants // J.Perinatol.2011.vol.31.№1.p.51-57.
Bernal NP. et al. Cerebral and somatic near-infrared speectroscopy in normal newbrorns // J.Pediatr.Surg.2016.v.451.№6.p.1306-1310.
McCormick PW et al. Noninvasive cereebral optical spectroscopy for monitoring cerebral oxygen delivery and hemodinamics // Crit.Care.Med.1991.vol.19.№1.p.89-97.
Yanowitz TD. Et al. Variability in cerebral oxygen delivery is reduced in premature neonates exposed to chorioamnionitis // Pediatr.Res. 2006.vol.59.№2,p.299-304.
Peng S, Boudes E, Tan X, Saint-Martin C, Shevell M. Winlermark P. Does near-infrared spectroscopy identify asphyxiated newborns at risk of developing brain injury during hypothermia treatment? // Am J Perinatal. (2015) 32:555-64. 10.1055/s-0034-1396692 [PubMed] [CrossRef] [Google Scholar].
Tekes A, Poretti A, Scheurkogel MM, Huismnn TAGM, Howlett JA, Alqahtani E. et al. Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury // Am J Neuroradiol. (2015)36:188-93.10.31.174/ajnr.A4083 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Jain SV, Pagano L. Gillam-Krakauer M, Slaughter JC. Pruthi S, Engelhardt B. Cerebral regional oxygen saturation trends in infants with hypoxic-ischemic encephalopathy // Early Hum Dev. (2017) 113:55-61. 10.l0l6/ j.earlhumdev.2017.07.008 [PubMed] [CrossRef] [Google Scholar].
Nakamura S, Koyano K, Jinnai W, Hamano S, Yasuda S, Konishi Y, et al Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by neur-infrared time-resolved spectroscopy // Brain Dev. (2015) 37:925- 32.10.1016/j.braindev.2015.04.002 [PubMed] [CrossRef] [Google Scholar].
Jöbsis FF. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters // Science. (1977) 198:1264-7. 10.1126/science.929199 [PubMed] [CrossRef] [Google Scholar].
Chalak LF, Tian F, Tarumı T, Zhang R. Cerebral hemodynamics in asphyxiated newborns undergoing hypothermia therapy: pilot findings using a multiple-time-scale analysis // Pediatr. Neurol. (2016) 55:30-6. 10.1016/j.pediatrneurol.2015.11.010 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Bale G, Mitra S, de Roever I, Chan M, Caicedo-Dorado A, Meek J, et al. Interrelationship between broadband NIRS measurements of cerebral cytochrome C oxidase and systemic changes indicates injury severity in neonatal encephalopathy // Adv Exp Med Biol. (2016) 923:181-6 10.1007/978-3-319-38810-6_24 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Mitra S, Bale G, Highton D, Gunny R., Uria-Avellanal C, Brainbridge A, et al. Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury // J Cereb Blood Flow Metab. (2017) 1:2716X17733639 10.1177/0271678X17733639 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Bale G, Mitra S, de Roever I, Sokolska M, Price D, Bainbridge A, et al. Oxygen dependency of mitochondrial metabolism indicates outcome of newborn brain injury // J Cereb Blood Flow Metab. (2018) 39, 2035-2047. 10.1177/0271678X18777928 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Mitra S, Bale G., de Roever I, Meek J, Robertson NJ. Tatchtsidis I. Changes in brain tissue oxygenation and metabolism during rewarming after neonatal encephalopathy are related to electrical abnormality // Adv Exp Med Biol. (2020) 1232:25-31. 10.1007/978-3-030- 34461-0_4 [PubMed] [CrossRef] [Google Scholar].
Lemmers PMA, Zwanenburg RJ, Benders MJNL, De Vries LS, Groenendaal F, Van Bel F, et al Cerebral oxygenation and brain activity after perinatal asphyxia: does hypothermia change their prognostic value? // PedialrRes. (2013) 74:180-5. 10.1038/pr.2013.84 [PubMed] [CrossRef] [Google Scholar].
Dehaes M, Aggarwal A, Lin PY, Rosa Fortuno C, Fenoglio A. Roche-Labarbe N, et al. Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia // J Cerebr Blood Plow Metab. (2014) 34:87-94. 10.1038/jcbfm.2013.165 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
Grant PE, Roche-Labarbe N, Surova A, Themelis G, Selb J, Warren EK, et al. Increased cerebral blood volume and oxygen consumption in neonatal brain injury // J Cerebr Blood Flow Metob. (2009): 29:1704-13. 10.1038/jcbfm.2009.90 [PMC free article] [PubMed] [CrossRef] [Google Scholar].
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