Cytogenetic Manifestations of Chromosomal Rearrangements in The Karyotype of Children with Attention Deficit and Hyperactivity Syndrome
DOI:
https://doi.org/10.61788/njn.v1i22.05Keywords:
attention deficit hyperactivity disorder, karyotype, Y-chromosome, phenotype, asocialityAbstract
In this article, based on a cytogenetic study of 62 children with attention deficit hyperactivity disorder, it was found that an increase in the length of the Y chromosome is associated with the development of attention deficit and hyperactivity syndrome. It is also one of the factors for predicting the likelihood of the formation of the syndrome and is used in screening and prenatal diagnostics, with the aim of early detection of a predisposition to the development of the syndrome and the adoption of preventive measures.
References
Bryant D.M., Hoeft F., Lai S., Lackey J., Roeltgen D., Ross J., Reiss A.L. Sex chromosomes and the brain: a study of neuroanatomy in XYY syndrome // Dev Med Child Neurol., 2012; 54(12):1149-56.
Cordeiro L., Tartaglia N., Roeltge., Rossc J. Social Deficits in Male Children and Adolescents with Sex Chromosome Aneuploidy: A Comparison of XXY, XYY, and XXYY syndromes // Res Dev Disabil., 2012; 33(4): 1254-1263.
Durand Christelle, Kappeler Caroline, Betancur Catalina , et al. Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders // Am J Med Genet B Neuropsychiatr Genet., 2006; 141(1): 67-70.
Lepage J.F., Hong D.S., Raman M., Marzelli M., Roeltgen D.P., Lai S., Ross J., Reiss A.L. Brain morphology in children with 47, XYY syndrome: a voxel- and surface-based morphometric study // Genes Brain Behav., 2014; 13(2):127-34.
Loke H., Harley V., Lee J. Biological factors underlying sex differences in neurological disorders // Int J Biochem Cell Biol., 2015; 65:139-50.
Tartaglia N.R., Ayari N., Hutaff-Lee C., Boada R. Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY // J Dev Behav Pediatr., 2012;33(4):309-18.
Paoloni-Giacobino A., Lespinasse J. Chromosome Y polysomy: a non-mosaic 49, XYYYY case // Clin Dysmorphol., 2007; 16(1): 65-66.
Ross J.L., Roeltgen D.P., Kushner H., Zinn A.R., Reiss A., Bardsley M.Z., McCauley E., Tartaglia N. Behavioral and social phenotypes in boys with 47, XYY syndrome or 47, XXY Klinefelter syndrome // Pediatrics., 2012; 129(4):769-78.
Mulligan A., Gill M., Fitzgerald M. A case of ADHD and a major Y chromosome abnormality // J Atten Disord., 2008; 12(1):103-5.
Ross J.L., Tartaglia N., Merry D.E ., Dalva M., Zinn A.R . Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features // Genes Brain Behav., 2015; 14(2):137-44.
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